Contact:
(203) 744-5905
Solid-State 13C NMR Study of Polymorphism
Solid-state 13C NMR is used extensively to study crystalline polymorphs and the relative crystalline and amorphous content of pharmaceutical excipients.
Process NMR Associates performs these studies on a dedicated Varian UnityPlus-200 spectrometer to yield spectral and relaxation data to allow the determination of drug-excipient interactions as well as simple polymorph differentiation and amorphous material content. Both 13C SP-MAS and CP-MAS experiments are utilized in these studies along with T1 and cross-relaxation time determinations.
Here are some excellent overviews of solid-state NMR applied to polymorphism : Robin Harris of Universityof Durham (my alma mater) and Cardiff School of Chemistry
An example of polymorphism determined by NMR in 4-azasteroid systems is given here....Morzycki et al...Steroids 67, 621 (2002).
The FDA have summarized the effects of polymorphism in pharmaceutical solids (PDF Version)
Please contact us below if you have a potential polymorph project that would benefit from solid-state NMR analysis
For more information on this topic please contact:
Manager, Process and Analytical NMR Services
Process NMR Associates LLC,
87A Sand Pit Rd
Danbury, CT 06810, USA
Tel: (203) 744-5905